New studies and trials, explained with their design, size and limits.
In a randomized trial of 100 adults, four weeks of thrice-weekly wall squats lowered systolic blood pressure, and one or two sessions a week were enough to hold the reduction for another four weeks.
In the ARMMS-T2D study's 11-year follow-up of 262 adults, 58% of those randomized to metabolic surgery achieved diabetes remission versus 3% with medical and lifestyle care; shorter diabetes duration predicted success.
A pooled analysis of 91,339 trial participants found antihypertensive treatment cut major cardiovascular events by 11% in people who took at least 80% of doses, with no significant benefit in those who took less.
In the 1,137-patient INTerpath-001 trial, adding the individualized mRNA therapy intismeran to pembrolizumab after surgery cut the risk of recurrence or death by 42%; overall survival data are not yet mature.
USC-led researchers used Britain's 1972 rise in the school-leaving age as a natural experiment: people made to stay in school longer were less likely to be diagnosed with dementia by 65, even at high genetic risk.
The EMA's human medicines committee recommended approval of Lilly's once-daily orforglipron pill on Oct. 15, as Viking started Phase 3 trials of oral VK2735 and Nature Medicine reported a Phase 3 trial of safiglipron.
In the TOSYMA trial of nearly 100,000 German women, tomosynthesis was followed by 29% fewer invasive interval cancers in the first year; the 24% two-year reduction was not statistically significant.
A cross-sectional study of 8,783 Canadian adults found the heaviest ultra-processed food consumers had 40% higher odds of MRI-detected vascular brain injury, with no difference in cognitive scores.
The SAVE-ICU trial of 780 ventilated adults in 14 Canadian ICUs found isoflurane-based sedation left hospital mortality unchanged at about 43%, with more rescue therapy for low oxygen and fewer delirium-free days.
Danish researchers found babies exposed to azole antifungal creams and vaginal tablets in the womb had altered adrenal hormone levels at three months, though still within the normal range.
